Fahren lernen Kaiserslautern für Dummies
Fahren lernen Kaiserslautern für Dummies
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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion rein this field that Aß may Beryllium produced from its precursor in a physiologically üblich pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.
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We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of our research.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
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Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht mehr wie 4 kW außerdem vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht mehr denn 6 kW, jeweils mit nicht eine größere anzahl wie alle zwei Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht etliche denn 45 kilometer pro stunde, einer maximalen Leermasse von 425 kg zumal einem Fremdzündungsmotor mit einem Hubraum von nicht mehr denn 50 cm³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht mehr Webseite denn 500 zentimeter³ oder einer anderen Antriebsform.
Together with an interdiziplinary team he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
einer elektrischen Antriebsmaschine oder einem Verbrennungsmotor mit einem Hubraum von nicht etliche als 50 zentimeter³ oder
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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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